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Preparation of hyaluronic acid-coated polymeric micelles for nasal vaccine delivery
http://hdl.handle.net/10112/00026085
http://hdl.handle.net/10112/000260851ec824c5-4949-4034-89c1-d9c9a41f56c0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KU-0020-20220126-01.pdf (2.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-01-26 | |||||
| タイトル | ||||||
| タイトル | Preparation of hyaluronic acid-coated polymeric micelles for nasal vaccine delivery | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Suzuki, Kengo
× Suzuki, Kengo× Yoshizaki, Yuta× Horii, Kenta× Murase, Nobuo× Kuzuya, Akinori× ⼤⽮, 裕⼀ |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50079 | |||||
| 姓名 | 堀井, 健大 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50080 | |||||
| 姓名 | 村瀬, 敦郎 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50081 | |||||
| 姓名 | 葛谷, 明紀 | |||||
| 概要 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Hyaluronic acid (HA)-coated biodegradable polymeric micelles were developed as nanoparticulate vaccine delivery systems to establish an effective nasal vaccine. We previously reported HA-coated micelles prepared by forming a polyion complex (PIC) of poly(L-lysine)-b-polylactide (PLys⁺-b-PLA) micelles and HA. The HA-coated micelles exhibited specific accumulation in HA receptor-expressing cells and extremely high colloidal stability under diluted blood conditions. In this study, a model antigen, ovalbumin (OVA), and an adjuvant oligonucleotide containing the CG motif (CpG-DNA) were efficiently loaded in HA-coated micelles via electrostatic interactions. HA-coated micelles delivered OVA and CpG-DNA in mouse bone marrow-derived dendritic cells (BMDCs) and resulted in upregulation of mRNA encoding IFN-γ and IL-4 in BMDCs. In addition, HA-coated micelles enhanced the expression of the major histocompatibility complex (MHC) class II on BMDCs. We investigated the immune response of HA-coated micelles following intranasal administration. HA-coated micelles induced higher OVA-specific IgG in the blood and OVA-specific IgA in the nasal wash than control (carboxymethyl dextran-coated) micelles. These results suggest that HA-coated micelles efficiently deliver antigens and adjuvants to mucosal-resident immune cells. Therefore, HA-coated micelles are promising platforms for developing nasal vaccines against infectious diseases. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This work was financially supported in part by the Private University Research Branding Project: Matching Fund Subsidy from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) Japan (2016–2020), Grants-in-Aid for Scientific Research (20H00670) from the Japan Society for the Promotion of Science (JSPS), and Kansai University Contingency Fund for Education and Research Outlay (2020). | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2020年度関西大学教育研究緊急支援経費 研究課題「高分子ミセルを用いた対コロナウイルス経鼻型ワクチンの開発」 |
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| 書誌情報 |
Biomaterials Science 巻 2022, p. 1-8, 発行日 2022-01-26 |
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| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 20474849 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12610795 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/d1bm01985f | |||||
| 権利 | ||||||
| 権利情報 | This is the author's version of the manuscript, Biomater. Sci., 2022,10, 1920-1928. The final version is available at https://doi.org/10.1039/D1BM01985F. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 出版者 | ||||||
| 出版者 | Royal Society of Chemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ナノ粒子 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nanoparticle | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ワクチン | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Vaccine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ドラッグデリバリーシステム | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Drug delivery system | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 高分子ミセル | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | polymeric micelle | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 生分解性ポリマー | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | biodegradable polymer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 関西大学 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Kansai University | |||||
