{"created":"2023-05-15T12:28:33.644012+00:00","id":22066,"links":{},"metadata":{"_buckets":{"deposit":"cb7b7386-e5e4-4c3a-900a-cddafc34167c"},"_deposit":{"created_by":10,"id":"22066","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"22066"},"status":"published"},"_oai":{"id":"oai:kansai-u.repo.nii.ac.jp:00022066","sets":["528:1588:1595:1597","63:71"]},"author_link":["50079","50082","34720","50078","50075","50080","50076","34729","50081","50077"],"item_9_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01-26","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"2022","bibliographic_titles":[{"bibliographic_title":"Biomaterials Science"}]}]},"item_9_description_4":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_description":"Hyaluronic acid (HA)-coated biodegradable polymeric micelles were developed as nanoparticulate vaccine delivery systems to establish an effective nasal vaccine. We previously reported HA-coated micelles prepared by forming a polyion complex (PIC) of poly(L-lysine)-b-polylactide (PLys⁺-b-PLA) micelles and HA. The HA-coated micelles exhibited specific accumulation in HA receptor-expressing cells and extremely high colloidal stability under diluted blood conditions. In this study, a model antigen, ovalbumin (OVA), and an adjuvant oligonucleotide containing the CG motif (CpG-DNA) were efficiently loaded in HA-coated micelles via electrostatic interactions. HA-coated micelles delivered OVA and CpG-DNA in mouse bone marrow-derived dendritic cells (BMDCs) and resulted in upregulation of mRNA encoding IFN-γ and IL-4 in BMDCs. In addition, HA-coated micelles enhanced the expression of the major histocompatibility complex (MHC) class II on BMDCs. We investigated the immune response of HA-coated micelles following intranasal administration. HA-coated micelles induced higher OVA-specific IgG in the blood and OVA-specific IgA in the nasal wash than control (carboxymethyl dextran-coated) micelles. These results suggest that HA-coated micelles efficiently deliver antigens and adjuvants to mucosal-resident immune cells. Therefore, HA-coated micelles are promising platforms for developing nasal vaccines against infectious diseases.","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This work was financially supported in part by the Private University Research Branding Project: Matching Fund Subsidy from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) Japan (2016–2020), Grants-in-Aid for Scientific Research (20H00670) from the Japan Society for the Promotion of Science (JSPS), and Kansai University Contingency Fund for Education and Research Outlay (2020).","subitem_description_type":"Other"},{"subitem_description":"2020年度関西大学教育研究緊急支援経費\n研究課題「高分子ミセルを用いた対コロナウイルス経鼻型ワクチンの開発」","subitem_description_type":"Other"}]},"item_9_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"50079","nameIdentifierScheme":"WEKO"}],"names":[{"name":"堀井, 健大"}]},{"nameIdentifiers":[{"nameIdentifier":"50080","nameIdentifierScheme":"WEKO"}],"names":[{"name":"村瀬, 敦郎"}]},{"nameIdentifiers":[{"nameIdentifier":"50081","nameIdentifierScheme":"WEKO"}],"names":[{"name":"葛谷, 明紀"}]},{"nameIdentifiers":[{"nameIdentifier":"50082","nameIdentifierScheme":"WEKO"}],"names":[{"name":"大矢, 裕一"}]}]},"item_9_publisher_34":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Royal Society of Chemistry"}]},"item_9_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1039/d1bm01985f","subitem_relation_type_select":"DOI"}}]},"item_9_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the author's version of the manuscript, Biomater. Sci., 2022,10, 1920-1928. The final version is available at https://doi.org/10.1039/D1BM01985F."}]},"item_9_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12610795","subitem_source_identifier_type":"NCID"}]},"item_9_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20474849","subitem_source_identifier_type":"ISSN"}]},"item_9_version_type_17":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Kengo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshizaki, Yuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horii, Kenta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murase, Nobuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuzuya, Akinori"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ohya, Yuichi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-14"}],"displaytype":"detail","filename":"KU-0020-20220126-01.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KU-0020-20220126-01.pdf","url":"https://kansai-u.repo.nii.ac.jp/record/22066/files/KU-0020-20220126-01.pdf"},"version_id":"92bbcf8e-ed32-4002-aa75-4704509033ca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ナノ粒子","subitem_subject_scheme":"Other"},{"subitem_subject":"Nanoparticle","subitem_subject_scheme":"Other"},{"subitem_subject":"ワクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"Vaccine","subitem_subject_scheme":"Other"},{"subitem_subject":"ドラッグデリバリーシステム","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug delivery system","subitem_subject_scheme":"Other"},{"subitem_subject":"高分子ミセル","subitem_subject_scheme":"Other"},{"subitem_subject":"polymeric micelle","subitem_subject_scheme":"Other"},{"subitem_subject":"生分解性ポリマー","subitem_subject_scheme":"Other"},{"subitem_subject":"biodegradable polymer","subitem_subject_scheme":"Other"},{"subitem_subject":"関西大学","subitem_subject_scheme":"Other"},{"subitem_subject":"Kansai University","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Preparation of hyaluronic acid-coated polymeric micelles for nasal vaccine delivery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Preparation of hyaluronic acid-coated polymeric micelles for nasal vaccine delivery"}]},"item_type_id":"9","owner":"10","path":["71","1597"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-01-26"},"publish_date":"2023-01-26","publish_status":"0","recid":"22066","relation_version_is_last":true,"title":["Preparation of hyaluronic acid-coated polymeric micelles for nasal vaccine delivery"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-05-15T16:14:12.645473+00:00"}