WEKO3
アイテム
Bone-targeting phospholipid polymers to solubilize the lipophilic anticancer drug
http://hdl.handle.net/10112/00020435
http://hdl.handle.net/10112/0002043539cc3094-494b-49b3-86aa-cd9e6735ea5d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KU-0020-20200422-01.pdf (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-22 | |||||
| タイトル | ||||||
| タイトル | Bone-targeting phospholipid polymers to solubilize the lipophilic anticancer drug | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
大高, 晋之
× 大高, 晋之× Yamaguchi, Tomoki× Saisho, Ryoya× Hiraga, Toru× 岩崎, 泰彦 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 40402 | |||||
| 姓名 | 大高, 晋之 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 40403 | |||||
| 姓名 | 山口, 知己 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 40404 | |||||
| 姓名 | 税所, 凌弥 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 40405 | |||||
| 姓名 | 平賀, 徹 | |||||
| 概要 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Current chemotherapy methods have limited effectiveness in eliminating bone metastasis, which leads to a poor prognosis associated with severe bone disorders. To provide regional chemotherapy for this metastatic tumor, a bone-targeting drug carrier was produced by introducing the osteotropic bisphosphonate alendronate (ALN) units into an amphiphilic phospholipid polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate). The polymer can form nanoparticles with a diameter of less than 30 nm; ALN units were exposed to the outer layer of the particle. A simple mixing procedure was used to encapsulate a hydrophobic anticancer drug, known as docetaxel (DTX), in the polymer nanoparticle, providing a uniform solution of a polymer-DTX complex in the aqueous phase. The complex showed anticancer activities against several breast cancer cell lines, and the complex formation did not hamper the pharmacological effect of DTX. The fluorescence observations evaluated by an in vivo imaging system and fluorescence microscopy showed that the addition of ALN to the polymer-DTX complex enhanced bone accumulation. Bone-targeting phospholipid polymers are potential solubilizing excipients used to formulate DTX and deliver the hydrophobic drug to bone tissues by blood administration. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | This work was supported by the Grant-in-Aid for Challenging Research (Exploratory) (No. 18K19656) from the Japan Society for the Promotion of Science, MEXT Private University Research Branding Project, and by Kansai University Fund for Supporting Young Scholars, 2018. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2018年度関西大学若手研究者育成経費 | |||||
| 書誌情報 |
Journal of Biomedical Materials Research Part A 巻 108, 号 10, p. 2090-2099, 発行日 2020-04-22 |
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| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 15493296 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11881516 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/jbm.a.36968 | |||||
| 権利 | ||||||
| 権利情報 | This is the peer reviewed version of the following article: Bone‐targeting phospholipid polymers to solubilize the lipophilic anticancer drug, A. Otaka, T. Yamaguchi, R. Saisho, T. Hiraga, Y. Iwasaki, Journal of Biomedical Materials Research Part A 2020, which has been published in final form at https://doi.org/10.1002/jbm.a.36968. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 出版者 | ||||||
| 出版者 | Wiley | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 骨転移 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bone metastasis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MPC | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 2-methacryloyloxyethyl phosphorylcholine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | アレンドロネート | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | alendronate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ドセタキセル | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | docetaxel | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 乳がん細胞 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | breast cancer cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 関西大学 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Kansai University | |||||
