{"created":"2023-05-15T12:24:19.490852+00:00","id":16383,"links":{},"metadata":{"_buckets":{"deposit":"76290376-80ab-4c70-92e3-ecf56837a0e9"},"_deposit":{"created_by":10,"id":"16383","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"16383"},"status":"published"},"_oai":{"id":"oai:kansai-u.repo.nii.ac.jp:00016383","sets":["499:2141","63:2140"]},"author_link":["40397","40405","40400","40404","40402","40401","40399","40403","40398"],"control_number":"16383","item_9_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"2099","bibliographicPageStart":"2090","bibliographicVolumeNumber":"108","bibliographic_titles":[{"bibliographic_title":"Journal of Biomedical Materials Research Part A"}]}]},"item_9_description_4":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_description":"Current chemotherapy methods have limited effectiveness in eliminating bone metastasis, which leads to a poor prognosis associated with severe bone disorders. To provide regional chemotherapy for this metastatic tumor, a bone-targeting drug carrier was produced by introducing the osteotropic bisphosphonate alendronate (ALN) units into an amphiphilic phospholipid polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate). The polymer can form nanoparticles with a diameter of less than 30 nm; ALN units were exposed to the outer layer of the particle. A simple mixing procedure was used to encapsulate a hydrophobic anticancer drug, known as docetaxel (DTX), in the polymer nanoparticle, providing a uniform solution of a polymer-DTX complex in the aqueous phase. The complex showed anticancer activities against several breast cancer cell lines, and the complex formation did not hamper the pharmacological effect of DTX. The fluorescence observations evaluated by an in vivo imaging system and fluorescence microscopy showed that the addition of ALN to the polymer-DTX complex enhanced bone accumulation. Bone-targeting phospholipid polymers are potential solubilizing excipients used to formulate DTX and deliver the hydrophobic drug to bone tissues by blood administration.","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This work was supported by the Grant-in-Aid for Challenging Research (Exploratory) (No. 18K19656) from the Japan Society for the Promotion of Science, MEXT Private University Research Branding Project, and by Kansai University Fund for Supporting Young Scholars, 2018.","subitem_description_type":"Other"},{"subitem_description":"2018年度関西大学若手研究者育成経費","subitem_description_type":"Other"}]},"item_9_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"40402","nameIdentifierScheme":"WEKO"}],"names":[{"name":"大高, 晋之"}]},{"nameIdentifiers":[{"nameIdentifier":"40403","nameIdentifierScheme":"WEKO"}],"names":[{"name":"山口, 知己"}]},{"nameIdentifiers":[{"nameIdentifier":"40404","nameIdentifierScheme":"WEKO"}],"names":[{"name":"税所, 凌弥"}]},{"nameIdentifiers":[{"nameIdentifier":"40405","nameIdentifierScheme":"WEKO"}],"names":[{"name":"平賀, 徹"}]}]},"item_9_publisher_34":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_9_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/jbm.a.36968","subitem_relation_type_select":"DOI"}}]},"item_9_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: Bone‐targeting phospholipid polymers to solubilize the lipophilic anticancer drug, A. Otaka, T. Yamaguchi, R. Saisho, T. Hiraga, Y. Iwasaki, Journal of Biomedical Materials Research Part A 2020, which has been published in final form at https://doi.org/10.1002/jbm.a.36968. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."}]},"item_9_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11881516","subitem_source_identifier_type":"NCID"}]},"item_9_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15493296","subitem_source_identifier_type":"PISSN"}]},"item_9_version_type_17":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大高, 晋之","creatorNameLang":"ja"},{"creatorName":"Otaka, Akihisa","creatorNameLang":"en"}],"familyNames":[{"familyName":"大高","familyNameLang":"ja"},{"familyName":"Otaka","familyNameLang":"en"}],"givenNames":[{"givenName":"晋之","givenNameLang":"ja"},{"givenName":"Akihisa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40397","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30739561","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000030739561"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Tomoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saisho, Ryoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiraga, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40400","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70322170","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000070322170"}]},{"creatorNames":[{"creatorName":"Iwasaki, Yasuhiko","creatorNameLang":"en"},{"creatorName":"岩崎, 泰彦","creatorNameLang":"ja"}],"familyNames":[{"familyName":"岩崎","familyNameLang":"ja"},{"familyName":"Iwasaki","familyNameLang":"en"}],"givenNames":[{"givenName":"泰彦","givenNameLang":"ja"},{"givenName":"Yasuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40401","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90280990","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000090280990"},{"nameIdentifier":"0000-0003-1603-6174","nameIdentifierScheme":"ORCID iD","nameIdentifierURI":"https://orcid.org/0000-0003-1603-6174"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"KU-0020-20200422-01.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KU-0020-20200422-01.pdf","url":"https://kansai-u.repo.nii.ac.jp/record/16383/files/KU-0020-20200422-01.pdf"},"version_id":"bf349351-dbcd-4521-b497-cc3a2729d3d3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨転移","subitem_subject_scheme":"Other"},{"subitem_subject":"bone metastasis","subitem_subject_scheme":"Other"},{"subitem_subject":"MPC","subitem_subject_scheme":"Other"},{"subitem_subject":"2-methacryloyloxyethyl phosphorylcholine","subitem_subject_scheme":"Other"},{"subitem_subject":"アレンドロネート","subitem_subject_scheme":"Other"},{"subitem_subject":"alendronate","subitem_subject_scheme":"Other"},{"subitem_subject":"ドセタキセル","subitem_subject_scheme":"Other"},{"subitem_subject":"docetaxel","subitem_subject_scheme":"Other"},{"subitem_subject":"乳がん細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"breast cancer cell","subitem_subject_scheme":"Other"},{"subitem_subject":"関西大学","subitem_subject_scheme":"Other"},{"subitem_subject":"Kansai University","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Bone-targeting phospholipid polymers to solubilize the lipophilic anticancer drug","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bone-targeting phospholipid polymers to solubilize the lipophilic anticancer drug","subitem_title_language":"en"}]},"item_type_id":"9","owner":"10","path":["2140","2141"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"16383","relation_version_is_last":true,"title":["Bone-targeting phospholipid polymers to solubilize the lipophilic anticancer drug"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2024-05-29T03:18:02.890971+00:00"}