WEKO3
アイテム
Application of On-line Electrochemistry/Electrospray/Tandem Mass Spectrometry to a Quantification Method for the Antipsychotic Drug Zotepine in Human Serum
http://hdl.handle.net/10112/5943
http://hdl.handle.net/10112/594394c8a72a-7a89-45a2-b368-3fbd34e5ce8d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KU-1100-20090911-05.pdf (452.9 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2012-01-26 | |||||||||
| タイトル | ||||||||||
| タイトル | Application of On-line Electrochemistry/Electrospray/Tandem Mass Spectrometry to a Quantification Method for the Antipsychotic Drug Zotepine in Human Serum | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Nozaki, Kazuyoshi
× Nozaki, Kazuyoshi× Osaka, Issey× 川崎, 英也
WEKO
2290
× Arakawa, Ryuichi |
|||||||||
| 著者別名 | ||||||||||
| 識別子Scheme | WEKO | |||||||||
| 識別子 | 26307 | |||||||||
| 姓名 | 野崎, 和吉 | |||||||||
| 著者別名 | ||||||||||
| 識別子Scheme | WEKO | |||||||||
| 識別子 | 26308 | |||||||||
| 姓名 | 大坂, 一生 | |||||||||
| 著者別名 | ||||||||||
| 識別子Scheme | WEKO | |||||||||
| 識別子 | 26310 | |||||||||
| 姓名 | 荒川, 隆一 | |||||||||
| 概要 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | A simple, rapid, and sensitive on-line liquid chromatographic electrochemistry/electrospray/tandem mass spectrometry (LC-EC/ESI-MS/MS) method for the determination of zotepine in human serum was developed using a new generated-electrochemically fragment ion, and was validated. A recent novel technique of LC-EC/ESI-MS/MS that combines LC-MS/MS and the on-line EC reaction is potentially applicable to developing a quantification method for drugs in biological samples. Newly formed products generated by the on-line EC cell are expected to provide appropriate precursor and product ions for the MS/MS determination method. This technique was successfully applied to a drug assay in a biological matrix. After adding imipramine (IS) to a 30-μL aliquot of human serum, the resulting sample was simply deproteinated with acetonitrile for a measurement. The analytical run time was 5 min. The calibration curve was linear in the concentration range of 10 − 2000 ng/mL. The intra-assay precision and accuracy were in the range of 1.8 − 8.9 and 98.4 − 113%, respectively. | |||||||||
| 書誌情報 |
Analytical Sciences 巻 25, 号 10, p. 1197-1201, 発行日 2009-10-10 |
|||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 09106340 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA10500785 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.2116/analsci.25.1197 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 出版者 | ||||||||||
| 出版者 | The Japan Society for Analytical Chemistry | |||||||||
| 出版者（他言語） | ||||||||||
| 値 | 日本分析化学会 | |||||||||
