{"created":"2023-05-15T12:20:45.905943+00:00","id":11445,"links":{},"metadata":{"_buckets":{"deposit":"c8f9cd0b-b185-4c51-b425-6adefd989497"},"_deposit":{"created_by":1,"id":"11445","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"11445"},"status":"published"},"_oai":{"id":"oai:kansai-u.repo.nii.ac.jp:00011445","sets":["528:1588:1595:1597"]},"author_link":["26303","26307","26306","26304","26308","26305","26310","26309"],"item_9_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-10-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1201","bibliographicPageStart":"1197","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Analytical Sciences"}]}]},"item_9_description_4":{"attribute_name":"概要","attribute_value_mlt":[{"subitem_description":"A simple, rapid, and sensitive on-line liquid chromatographic electrochemistry/electrospray/tandem mass spectrometry (LC-EC/ESI-MS/MS) method for the determination of zotepine in human serum was developed using a new generated-electrochemically fragment ion, and was validated. A recent novel technique of LC-EC/ESI-MS/MS that combines LC-MS/MS and the on-line EC reaction is potentially applicable to developing a quantification method for drugs in biological samples. Newly formed products generated by the on-line EC cell are expected to provide appropriate precursor and product ions for the MS/MS determination method. This technique was successfully applied to a drug assay in a biological matrix. After adding imipramine (IS) to a 30-μL aliquot of human serum, the resulting sample was simply deproteinated with acetonitrile for a measurement. The analytical run time was 5 min. The calibration curve was linear in the concentration range of 10 − 2000 ng/mL. The intra-assay precision and accuracy were in the range of 1.8 − 8.9 and 98.4 − 113%, respectively.","subitem_description_type":"Other"}]},"item_9_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"26307","nameIdentifierScheme":"WEKO"}],"names":[{"name":"野崎, 和吉"}]},{"nameIdentifiers":[{"nameIdentifier":"26308","nameIdentifierScheme":"WEKO"}],"names":[{"name":"大坂, 一生"}]},{"nameIdentifiers":[{"nameIdentifier":"26309","nameIdentifierScheme":"WEKO"}],"names":[{"name":"川崎, 英也"}]},{"nameIdentifiers":[{"nameIdentifier":"26310","nameIdentifierScheme":"WEKO"}],"names":[{"name":"荒川, 隆一"}]}]},"item_9_publisher_34":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Society for Analytical Chemistry"}]},"item_9_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2116/analsci.25.1197","subitem_relation_type_select":"DOI"}}]},"item_9_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10500785","subitem_source_identifier_type":"NCID"}]},"item_9_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09106340","subitem_source_identifier_type":"ISSN"}]},"item_9_text_35":{"attribute_name":"出版者（他言語）","attribute_value_mlt":[{"subitem_text_value":"日本分析化学会"}]},"item_9_version_type_17":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nozaki, Kazuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osaka, Issey"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawasaki, Hideya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Arakawa, Ryuichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-23"}],"displaytype":"detail","filename":"KU-1100-20090911-05.pdf","filesize":[{"value":"452.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KU-1100-20090911-05.pdf","url":"https://kansai-u.repo.nii.ac.jp/record/11445/files/KU-1100-20090911-05.pdf"},"version_id":"62ff8493-1b05-49b8-9928-185fe7a17a76"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Application of On-line Electrochemistry/Electrospray/Tandem Mass Spectrometry to a Quantification Method for the Antipsychotic Drug Zotepine in Human Serum","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Application of On-line Electrochemistry/Electrospray/Tandem Mass Spectrometry to a Quantification Method for the Antipsychotic Drug Zotepine in Human Serum"}]},"item_type_id":"9","owner":"1","path":["1597"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-01-26"},"publish_date":"2012-01-26","publish_status":"0","recid":"11445","relation_version_is_last":true,"title":["Application of On-line Electrochemistry/Electrospray/Tandem Mass Spectrometry to a Quantification Method for the Antipsychotic Drug Zotepine in Human Serum"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T14:40:42.892730+00:00"}