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Extracellular Water May Mask Actual Muscle Atrophy During Aging
http://hdl.handle.net/10112/6028
http://hdl.handle.net/10112/60284247fb52-149c-4d55-a126-ba8cc42cd247
| 名前 / ファイル | ライセンス | アクション |
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KU-1100-20091221-01.pdf (223.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-02-04 | |||||
| タイトル | ||||||
| タイトル | Extracellular Water May Mask Actual Muscle Atrophy During Aging | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamada, Yosuke
× Yamada, Yosuke× Schoeller, A. Dale× Nakamura, Eitaro× Morimoto, Taketoshi× Kimura, Misaka× 小田, 伸午 |
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| 概要 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background. \nSkeletal muscle tissue holds a large volume of water partitioned into extracellular water (ECW) and intracellular water (ICW) fractions. As the ECW may not be related to muscle strength directly, we hypothesized that excluding ECW from muscle volume would strengthen the correlation with muscle strength. Methods. \nA total of 119 healthy men aged 20–88 years old participated in this study. Knee isometric extension strength, vertical jump, and standing from a chair were measured as indices of muscle strength and power in the lower extremities. The regional lean volume (LV), total water (TW), ICW, and ECW in the lower leg were estimated by anthropometry (skinfold and circumference measurements) and segmental multifrequency bioelectrical impedance spectroscopy (S-BIS). Then, we calculated the ECW/TW and ICW/TW ratios. Results. \nAlthough ICW and the LV index decreased significantly with age (p < .001), no significant changes in ECW were observed (p = .134). Consequently, the ECW/TW ratio increased significantly (p < .001) with age (young adult, 27.0 ± 2.9%; elderly, 34.3 ± 4.9%; advanced elderly, 37.2 ± 7.0%). Adjusting for this by including the ICW/TW ratio in our models significantly improved the correlation between the LV index and strength-related measurements and correlated with strength-related measurements independently of the LV index (p < .001). Conclusions. \nThe ECW/TW ratio increases in the lower leg with age. The results suggest that the expansion of ECW relative to ICW and the LV masked actual muscle cell atrophy with aging. |
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| 書誌情報 |
The Journals of Gerontology: Series A, Biological Sciences and Medical Sciences 巻 65A, 号 5, p. 510-516, 発行日 2010-05 |
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| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 10795006 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/gerona/glq001 | |||||
| 権利 | ||||||
| 権利情報 | (c) Oxford University Press. This is final draft (Post print) version. The original publication is available at http://biomedgerontology.oxfordjournals.org/content/65A/5/510.full | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
