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ラットのオープンフィールド行動と物体探索行動に及ぼすMK-801の効果とその性差
http://hdl.handle.net/10112/6853
http://hdl.handle.net/10112/6853702991db-6388-4933-9949-8a4825f6cce4
名前 / ファイル | ライセンス | アクション |
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KU-1100-19981215-03.pdf (148.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-07-09 | |||||
タイトル | ||||||
タイトル | ラットのオープンフィールド行動と物体探索行動に及ぼすMK-801の効果とその性差 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
その他のタイトル | ||||||
その他のタイトル | The effect of MK-801 on openfield activities and object exploration and its sex difference | |||||
著者 |
関口, 理久子
× 関口, 理久子× 岸田, 明美 |
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著者別名 | ||||||
姓名 | Sekiguchi, Rikuko | |||||
著者別名 | ||||||
姓名 | Kishida, Akemi | |||||
概要 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The present study investigated the effect of MK-801 on openfield activities and object exploratory behavior in a circular openfield by using Sprague-Dawley rats. In Experiment 1,when a novel object was placed in a central zone (CZ) of the openfield, CZ-stay-time and CZ-stay-time-per-entry significantly increased, and no sex difference was shown for object exploratory behavior. In Experiment 2,MK-801(0.05,0.1,0.mg/kg) was administered i.p.. Marked dose-dependent sex difference in object exploratory behavior and openfield activities. CZ-stay-time, CZ-stay-time-per-entry, locomotion, rearing, and leaning of males were affected by 0.1 and 0.2 mg/kg of MK-801. Females given 0.05 mg/kg of MK-801,which did not affect locomotion in males, displayed hyperactivity, and those given 0.2 mg/kg a significant reduction of activity. Females, 0.1 and 0.2 mg/kg of MK-801 affected object exploratory behavior, locomotion, rearing and leaning even on the next day of administration. These results suggested that the effect of MK-801 in female rats tends to be longer than in males, and that females are more susceptible to non-competitive NMDA receptor blockade than males. | |||||
書誌情報 |
動物心理学研究 巻 48, 号 2, p. 161-176, 発行日 1998-12-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09168419 | |||||
権利 | ||||||
権利情報 | (C) 日本動物心理学会:SCPJに記載されている規約に従い、リンクを記載する。 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 日本動物心理学会 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MK-801 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ex difference | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | object exploratory behavior | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | openfield activities |