@article{oai:kansai-u.repo.nii.ac.jp:00009785,
 author = {関口, 理久子 and 岸田, 明美},
 issue = {2},
 journal = {動物心理学研究},
 month = {Dec},
 note = {The present study investigated the effect of MK-801 on openfield activities and　object exploratory behavior in a circular openfield by using Sprague-Dawley rats. In Experiment 1,when a novel object was placed in a central zone (CZ) of the openfield, CZ-stay-time and CZ-stay-time-per-entry significantly increased, and no sex difference was shown for object exploratory behavior. In Experiment 2,MK-801(0.05,0.1,0.mg/kg) was administered i.p.. Marked dose-dependent sex difference in object exploratory behavior and openfield activities. CZ-stay-time, CZ-stay-time-per-entry, locomotion, rearing, and leaning of males were affected by 0.1 and 0.2 mg/kg of MK-801. Females given 0.05 mg/kg of MK-801,which did not affect locomotion in males, displayed　hyperactivity, and those given 0.2 mg/kg a significant reduction of activity. Females, 0.1 and 0.2 mg/kg of MK-801 affected object exploratory behavior, locomotion, rearing and leaning even on the next day of administration. These results suggested that the effect of MK-801 in female rats tends to be longer than in males, and that females are more susceptible to non-competitive NMDA receptor blockade than males.},
 pages = {161--176},
 title = {ラットのオープンフィールド行動と物体探索行動に及ぼすMK-801の効果とその性差},
 volume = {48},
 year = {1998}
}