@techreport{oai:kansai-u.repo.nii.ac.jp:00013566,
 author = {Takata, Kazuyuki and Takai, Hiroki and Yoshizaki, Yuta and Nagata, Takuya and Kawahara, Keisuke and Yoshida, Yasuyuki and Kuzuya, Akinori and Ohya, Yuichi},
 month = {},
 note = {We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40)) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents., P.4~P.14
Title: Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation
Journal: Gels 
Doi:https://doi.org/10.3390/gels3040038, 本研究の⼀部は 2016-2017 年度関⻄⼤学研究拠点形成⽀援経費において，研究課題「ゾル−ゲル転移を⽰す⽣体適合ポリマー材料の開発と応⽤」として研究費を受け，その成果を公表するものである。},
 title = {ゾルーゲル転移を示す生体適合ポリマー材料の開発と応用 (1)},
 year = {2019}
}