@article{oai:kansai-u.repo.nii.ac.jp:00011450,
 author = {Nozaki, Kazuyoshi and Tarui, Akira and Osaka, Issey and Kawasaki, Hideya and Arakawa, Ryuichi},
 issue = {6},
 journal = {Analytical Sciences},
 month = {Jun},
 note = {The effects of an on-line ion suppressor device on alkali metal ion adduct formations of the model compound tacrolimus were investigated. The base peak ion in the positive ion ESI-MS spectrum of tacrolimus was a sodium ion adduct, [M+Na]+. On the other hand, an ammonium ion adduct, [M+NH4]+, was the base peak ion in the full-scan mass spectrum of tacrolimus with a cation-exchange suppressor resin, and both [M+Na]+ and [M+K]+ were eliminated. These results indicate that the combination of an on-line ion suppressor with ESI-MS is a simple and effective technique that eliminates undesirable alkali metal ion adduct formations in the positive-ion mode.},
 pages = {715--718},
 title = {Elimination technique for alkali metal ion adducts from an electrospray ionization process using an on-line ion suppressor},
 volume = {26},
 year = {2010}
}