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oai:kansai-u.repo.nii.ac.jp:00011542 2024-10-30T02:52:09Z 528:1588:1595:1597

Influence of Crystalline Forms of Titania on Desorption/Ionization Efficiency in Titania-Based Surface-Assisted Laser Desorption/Ionization Mass Spectrometry 50322285 川崎, 英也 Kawasaki, Hideya 川崎 Kawasaki 英也 Hideya Okumura, Kouji Arakawa, Ryuichi Titania SALDI-MS Crystalline forms In surface-assisted laser desorption/ionization mass spectrometry using titania (TiO2) films (TiO2-SALDI-MS), one of the most important aspects is the absence of matrix interferences in the low-mass region. Therefore, in TiO2-SALDI, the detectable mass range for small biomolecules, pharmaceutical compounds, amino acids, and oligopeptides can be extended to below m/z 500. The physicochemical properties of titania are dependent on the crystalline form of the material; however, thus far, very little attention has been given to the effect of the crystalline form of titania on titania-based SALDI-MS. We investigated the influence of crystalline forms on the desorption/ionization efficiency of TiO2-based SALDI-MS using different crystalline forms such as rutile, anatase, and a non-crystalline amorphous structure. On the basis of survival yield measurements using benzylpyridium chloride, and the desorption/ionization efficiency of peptides (angiotensin II and gly-gly-tyr-arg) and saccharides (cellobiose and hexa-N-acetyl-chitohexaose), it was found that the anatase-type TiO2 is suitable for the TiO2-based SALDI-MS. Rutile-type TiO2 lost the SALDI activity compared with TiO2 in other crystalline forms, although rutile-type TiO2 showed the highest UV absorbance. Mass Spectrometry Society of Japan 2010 eng journal article VoR http://hdl.handle.net/10112/6003 https://kansai-u.repo.nii.ac.jp/records/11542 10.5702/massspec.58.221 AA1254271X 13408097 Journal of the Mass Spectrometry Society of Japan 58 6 221 228 https://kansai-u.repo.nii.ac.jp/record/11542/files/KU-1100-20100000-04.pdf application/pdf 511.0 kB 2019-05-23