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Flow across microvessel walls through the endothelial surface glycocalyx and the interendothelial cleft
http://hdl.handle.net/10112/7867
http://hdl.handle.net/10112/78679783ae95-983c-4ebb-b5c8-3299b53f7ae5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KU-1100-20080000-15.pdf (539.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-17 | |||||
| タイトル | ||||||
| タイトル | Flow across microvessel walls through the endothelial surface glycocalyx and the interendothelial cleft | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sugihara-seki, Masako
× Sugihara-seki, Masako× 秋永, 剛× Itano, Tomoaki |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 24073 | |||||
| 姓名 | 関, 眞佐子 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 24074 | |||||
| 姓名 | 秋永, 剛 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 24075 | |||||
| 姓名 | 板野, 智昭 | |||||
| 概要 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | A mathematical model is presented for steady fluid flow across microvessel walls through a serial pathway consisting of the endothelial surface glycocalyx and the intercellular cleft between adjacent endothelial cells, with junction strands and their discontinuous gaps. The three-dimensional flow through the pathway from the vessel lumen to the tissue space has been computed numerically based on a Brinkman equation with appropriate values of the Darcy permeability. The predicted values of the hydraulic conductivity Lp, defined as the ratio of the flow rate per unit surface area of the vessel wall to the pressure drop across it, are close to experimental measurements for rat mesentery microvessels. If the values of the Darcy permeability for the surface glycocalyx are determined based on the regular arrangements of fibres with 6 nm radius and 8 nm spacing proposed recently from the detailed structural measurements, then the present study suggests that the surface glycocalyx could be much less resistant to flow compared to previous estimates by the one-dimensional flow analyses, and the intercellular cleft could be a major determinant of the hydraulic conductivity of the microvessel wall. |
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| 書誌情報 |
Journal of Fluid Mechanics 巻 601, p. 229-252, 発行日 2008 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00221120 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00698198 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1017/s0022112008000530 | |||||
| 権利 | ||||||
| 権利情報 | (C) Cambridge University Press : Original text is available at http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1846488 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Cambridge University Press | |||||
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Cite as
Sugihara-seki, Masako, 秋永, 剛, Itano, Tomoaki, 2008, Flow across microvessel walls through the endothelial surface glycocalyx and the interendothelial cleft: Cambridge University Press, 229–252 p.
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