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Charge effects on the hindered transport of macromolecules across the endothelial surface glycocalyx layer
http://hdl.handle.net/10112/7854
http://hdl.handle.net/10112/785493d83054-33ba-4e1c-b158-bace3497341e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KU-1100-20120000-10.pdf (295.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-05 | |||||
| タイトル | ||||||
| タイトル | Charge effects on the hindered transport of macromolecules across the endothelial surface glycocalyx layer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sugihara-seki, Masako
× Sugihara-seki, Masako× 秋永, 剛× O-tani, Hideyuki |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 23894 | |||||
| 姓名 | 関, 眞佐子 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 23895 | |||||
| 姓名 | 秋永, 剛 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 23896 | |||||
| 姓名 | 大谷, 英之 | |||||
| 概要 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | A fluid mechanical and electrostatic model for the transport of solute molecules across the vascular endothelial surface glycocalyx layer (EGL) was developed to study the charge effect on the diffusive and convective transport of the solutes. The solute was assumed to be a spherical particle with a constant surface charge density, and the EGL was represented as an array of periodically arranged circular cylinders of like charge, with a constant surface charge density. By combining the fluid mechanical analyses for the flow around a solute suspended in an electrolyte solution and the electrostatic analyses for the free energy of the interaction between the solute and cylinders based on a mean field theory, we estimated the transport coefficients of the solute across the EGL. Both of diffusive and convective transports are reduced compared to those for an uncharged system, due to the stronger exclusion of the solute that results from the repulsive electrostatic interaction. The model prediction for the reflection coefficient for serum albumin agreed well with experimental observations if the charge density in the EGL is ranged from approximately −10 to −30 mEq/l. | |||||
| 書誌情報 |
Biorheology 巻 49, p. 301-316, 発行日 2012 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006355X | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 18785034 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3233/bir-120620 | |||||
| 権利 | ||||||
| 権利情報 | (C)IOS Press: Original text is available at http://iospress.metapress.com/content/j422x311115q7235/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | IOS Press | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Debye–Hückel equation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Boltzmann factor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | reflection coefficient | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hindrance factors | |||||
