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Application of On-line Electrochemistry/Electrospray/Tandem Mass Spectrometry to a Quantification Method for the Antipsychotic Drug Zotepine in Human Serum
http://hdl.handle.net/10112/5943
http://hdl.handle.net/10112/594394c8a72a-7a89-45a2-b368-3fbd34e5ce8d
名前 / ファイル | ライセンス | アクション |
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KU-1100-20090911-05.pdf (452.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-01-26 | |||||
タイトル | ||||||
タイトル | Application of On-line Electrochemistry/Electrospray/Tandem Mass Spectrometry to a Quantification Method for the Antipsychotic Drug Zotepine in Human Serum | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nozaki, Kazuyoshi
× Nozaki, Kazuyoshi× Osaka, Issey× Kawasaki, Hideya× Arakawa, Ryuichi |
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著者別名 | ||||||
姓名 | 野崎, 和吉 | |||||
著者別名 | ||||||
姓名 | 大坂, 一生 | |||||
著者別名 | ||||||
姓名 | 川崎, 英也 | |||||
著者別名 | ||||||
姓名 | 荒川, 隆一 | |||||
概要 | ||||||
内容記述タイプ | Other | |||||
内容記述 | A simple, rapid, and sensitive on-line liquid chromatographic electrochemistry/electrospray/tandem mass spectrometry (LC-EC/ESI-MS/MS) method for the determination of zotepine in human serum was developed using a new generated-electrochemically fragment ion, and was validated. A recent novel technique of LC-EC/ESI-MS/MS that combines LC-MS/MS and the on-line EC reaction is potentially applicable to developing a quantification method for drugs in biological samples. Newly formed products generated by the on-line EC cell are expected to provide appropriate precursor and product ions for the MS/MS determination method. This technique was successfully applied to a drug assay in a biological matrix. After adding imipramine (IS) to a 30-μL aliquot of human serum, the resulting sample was simply deproteinated with acetonitrile for a measurement. The analytical run time was 5 min. The calibration curve was linear in the concentration range of 10 − 2000 ng/mL. The intra-assay precision and accuracy were in the range of 1.8 − 8.9 and 98.4 − 113%, respectively. | |||||
書誌情報 |
Analytical Sciences 巻 25, 号 10, p. 1197-1201, 発行日 2009-10-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09106340 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10500785 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2116/analsci.25.1197 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | The Japan Society for Analytical Chemistry | |||||
出版者(他言語) | ||||||
日本分析化学会 |